mme_hardy: White rose (Default)
[personal profile] mme_hardy
Three different preventative drugs for migraine are in late-stage trials and doing well. This is a big damn deal. There are drugs that are abortives -- once you start feeling migraine symptoms, you take them to drastically reduce those symptoms -- but all the preventatives are off-label for something else.

To give you some idea, the preventatives I take are:
  • Lyrica (Federally approved for seizures, neuropathic pain, and fibromyalgia)
  • Botox (Federally approved for torticollis, lots of other clenched-muscle conditions, and various kinds of cosmetic uses)
In the past I have tried beta and calcium-channel blockers (high blood pressure), multiple anti-epileptics, and IIRC one antihistamine that had to be special-ordered from Canada.

The migraine-specific triptan drugs, when they were introduced, were a revolution: instead of blunting the pain you were short-circuiting the migraine cycle.   I have hopes that one of these three drugs will be a similar game-changer for prevention.  Fingers crossed.

In the meantime, I'm overdue for a Botox treatment; will schedule tomorrow.



Date: 2017-07-06 02:21 am (UTC)
laurashapiro: a woman sits at a kitchen table reading a book, cup of tea in hand. Table has a sliced apple and teapot. A cat looks on. (Default)
From: [personal profile] laurashapiro
OMG such good news! I'm seeing my migraine practitioner Friday and will mention.

Date: 2017-07-06 03:53 am (UTC)
pameladean: (Default)
From: [personal profile] pameladean
Oooh, that sounds like a genuine breakthrough, and I know so many people these drugs would help if they worked. Fingers really seriously crossed.

P.

Date: 2017-07-06 04:06 am (UTC)
sovay: (Sovay: David Owen)
From: [personal profile] sovay
I have hopes that one of these three drugs will be a similar game-changer for prevention. Fingers crossed.

Amen!

Date: 2017-07-06 08:28 am (UTC)
oursin: Swirly spiralling colours in a vortexy shape (vortex)
From: [personal profile] oursin
Indeed we may hope - pizotifen/sanomigran worked for me for years but then stopped and amitryptiline was fairly useless (though had a side benefit in reducing lower back problem). Must see what the Migraine Trust has to say about these.

Date: 2017-07-06 09:04 am (UTC)
lilysea: Tree hugger (Tree hugger)
From: [personal profile] lilysea
I am very excite!

I've been getting more migraines as I wean myself off Lyrica (I just could not cope with Lyrica, for many many reasons), and I have to go to great lengths to avoid my triggers.

- fragrance / air freshener
- noise
- fluorescent lights
- sunlight
- low blood sugar
- high blood sugar

Date: 2017-07-06 12:41 pm (UTC)
oracne: turtle (Default)
From: [personal profile] oracne
EXCELLENT news.

Date: 2017-07-06 03:24 pm (UTC)
nestra: (Default)
From: [personal profile] nestra
Fingers crossed for sure. Nortriptyline has worked well for me as a preventive, thank god, but I suspect nothing lasts forever on that front.

I've never found an abortive that works, though that's partially because I'm real bad at noticing that a migraine is coming on. I did try the Zomig nasal spray, which made a dent in an existing migraine, and might actually work if I can catch the damn headache at the beginning.

Date: 2017-07-06 05:27 pm (UTC)
wild_irises: (piglet balloon)
From: [personal profile] wild_irises
Fabulous!

I recently have had three friends diagnosed with 1) "complicated migraine" which presents as TIA or stroke; 2) "abdominal migraine" and 3) "vestibular migraine" in a person who has had uncontrollable dizziness/vertigo for years.

I wonder if we will end up with drugs, preventative and abortive, for specific non-headache migraines.

Date: 2017-07-06 06:21 pm (UTC)
sabotabby: (gaudeamus)
From: [personal profile] sabotabby
Relevant to my interests.

OMG I hope it works for you.

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